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Quantitative Proteomics Center
Department of Biological Sciences
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Concept of Center: Collaboration

The concept is based on the development of projects supporting the ongoing research programs of collaborating laboratories.  This strategy leverages the specialized expertise and equipment in proteomics available at the center, and has the potential for significantly advancing the research projects of the collaborators.

Quantitative proteomics is a complex technology regardless of the particular techniques used.  Our strategy is to conduct the proteomics work within the center as comprehensive collaborative projects.  The work done includes a complete package of activities designed to complete a mutually agreed upon scope of work.  Pilot (exploratory) projects of minimal scope can also be performed.  A typical project includes:
  • Planning and comprehensive consultation
  • Training and consultation on sample preparation
  • Provision of tested and certified reagents and protocols for protein sample preparation
  • Consultation on experimental design
  • Publication quality, fully analyzed, validated and interpreted data
  • Advice about limitations of results
  • Validation and summarization of results
  • Consultation on results interpretation
  • Consultation in higher level systems biology interpretations
  • Supported for the development of grant proposals including the development of preliminary data
  • Participation in project meetings
  • Comprehensive support in preparing data for publication
  • Support for manuscript revision in response to reviewer comments
  • Support for revision of grant proposals in response to reviewer comments
  • Consultation on strategies for validation of results by corroborative methods not involving proteomics methods
The center maintains expertise and equipment for the many components of modern proteomics.  It is impractical for each collaborating laboratory to acquire the equipment and skills needed for this specialized work.

A Proteomics Advisory Committee aids the director in setting policies for the center and in prioritizing activities. 

Funding a New Project

Funds for executing the projects are derived from project or program grants awarded to the collaborating PI or jointly with the Center Director.  These can be existing projects or new projects proposed with support of the center.  In the latter case help with grant proposals is available from the Center Director.  The support and development of comprehensive shared efforts such as these is a challenge to modern life science.  Potential collaborators should review a paper written by the
Executive Board of the Association of Biomolecular Resource Facilities that deals with these challenges.  Ordinarily, the Center Director is listed under key personnel in such collaborative grants or as co-investigator, and an appropropriate amount for the work is included in the proprosal budget.

Interested in beginning a new project?

The first step is to contact the director to discuss your possible project.  Also watch our education and news pages for notices of seminars and talks that may provide some ideas about how this technology may be useful in your work.