Columbia University, all rights reserved.
Quantitative Proteomics Center
Department of Biological Sciences
Chemical Probe Synthesis

We have partnered with the Columbia NYSTEM Chemical Probe Synthesis (CPS) Facility on the Morningside campus of Columbia University. The CPS facility designs and synthesizes small molecule probes and develops conjugation chemistry for attachment of molecules to surfaces.  The close collaboration between the CPS and the QPC has resulted in a highly productive platform for systematic detection of protein targets of small molecules. Quantitative protein target detection in these affinity experiments employs all-ion fragmentation, ion-mobility spectrometry and the use of massively parallel computational and data mining resources to provide a powerful innovative platform. This coordinated capability for discovery of protein targets of molecules in affinity experiments is available to interested researchers.  Please contact the QPC or CPS for further information.