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Concept of Center: Collaboration with Academic Labs and Companies
The concept is based on the development of projects supporting
the ongoing research programs of collaborating laboratories or
companies. Confidentiality is assured for collaborations with
corporate sponsorship. This strategy leverages the specialized expertise
and equipment in proteomics available at the center, and has the
potential for significantly advancing the research projects of the
collaborators.
Quantitative proteomics is a complex technology regardless of the
particular techniques used. Our strategy is to conduct the
proteomics work within the center as comprehensive collaborative
projects. The work done includes a complete package of activities
designed to complete a mutually agreed upon scope of work. Pilot
(exploratory) projects of minimal scope can also be performed. A
typical project includes:
Planning and comprehensive consultation
Training and consultation on sample preparation
Provision of tested and certified reagents and protocols for protein sample preparation
Consultation on experimental design
Publication quality, fully analyzed, validated and interpreted data
Advice about limitations of results
Validation and summarization of results
Consultation on results interpretation
Consultation in higher level systems biology interpretations
Supported for the development of grant proposals including the development of preliminary data
Participation in project meetings
Comprehensive support in preparing data for publication
Support for manuscript revision in response to reviewer comments
Support for revision of grant proposals in response to reviewer comments
Consultation on strategies for validation of results by corroborative methods not involving proteomics methods
The center maintains expertise and equipment for the
many components of modern proteomics. It is impractical for each
collaborating laboratory to acquire the equipment and skills needed for
this specialized work.
An Advisory Committee aids the director in setting policies for the center and in prioritizing activities.
Funding a New Project
Funds for executing the projects are derived from project or
program grants awarded to the collaborating PI or jointly with the
Center Director. These can be existing projects or new projects
proposed with support of the center. In the latter case help with
grant proposals is available from the Center Director. The support
and development of comprehensive shared efforts such as these is a
challenge to modern life science. Potential collaborators should
review a paper written by the Executive Board of the Association of Biomolecular Resource Facilities
that deals with these challenges. Ordinarily, the Center Director
is listed under key personnel in such collaborative grants or as
co-investigator, and an appropropriate amount for the work is included
in the proprosal budget.
Interested in beginning a new project?
The first step is to contact the director to discuss your possible project.
Scientific Partner We have partnered with the Columbia NYSTEM Chemical Probe
Synthesis (CPS) Facility on the Morningside campus of Columbia
University. The CPS facility designs and synthesizes small molecule
probes and develops conjugation chemistry for attachment of molecules to
surfaces. The close collaboration between the CPS and the QPC has
resulted in a highly productive platform for systematic detection of
protein targets of small molecules. Quantitative protein target
detection in these affinity experiments employs all-ion fragmentation,
ion-mobility spectrometry and the use of massively parallel
computational and data mining resources to provide a powerful innovative
platform. This coordinated capability for discovery of protein targets
of molecules in affinity experiments is available to interested
researchers. Please contact the QPMC or CPS for further information.